extra-, extro-, extr-, exter-

1. Located outside territorial boundaries; such as, fishing in extraterritorial waters.
2. Of or relating to persons exempt from the legal jurisdiction of the country in which they reside.

Exemption from local legal jurisdiction; such as, that granted to foreign diplomats.

1. Outside of blood or lymph vessels; not contained in the body's blood or lymph vessels.
2. Located or occurring outside a blood or lymph vessel.

1. Highest in intensity or degree: "She has been able to withstand extreme pressure as a nurse."
2. Not reasonable; going far beyond what is reasonable, moderate, or normal: "Our son had an extreme reaction to the medication."
3. Farthest out, especially from the center; most remote in any direction; outermost or farthest; such as, the extreme north of the country.
4. Very strict or severe; of the greatest severity; drastic: "While traveling by air, we experienced extreme and costly security measures."
5. Describes sports or leisure activities in which participants actively seek out dangerous or even life-threatening experiences; such as, extreme rafting or an extreme skier.
6. Being in or attaining the greatest or highest degree; very intense: extreme pleasure; extreme pain.
7. Etymology: from Latin extremus, "outermost, utmost"; superlative of exter, exterus, "on the outside, outward, external, foreign, strange".

A classification for a weather event that is very different from the "normal" range of weather experienced in the given location; such as, a flood, drought, tornado, blizzard, ice storm, heat wave, or cold spell, etc.

There are microbes that thrive under conditions that would kill other creatures; yet, many microorganisms make their homes in such forbidding environments as boiling or near freezing water, vinegar-like liquids, household ammonia, or concentrated brine.

These microbes are called extremophiles because they thrive under conditions that, from the human position, are clearly extreme. Scientists have recognized that places once assumed to be sterile abound with microbial life.